notch pathway

Notch1/CSL Reporter Kit (Notch Signaling Pathway)
60509 500 rxns.
EUR 590
Description: The Notch Pathway Reporter kit is designed for monitoring the activity of Notch signaling pathway in the cultured cells. The kit contains the transfection-ready expression vector for Notch1 with the entire extracellular domain deleted (Notch1DE). Inside the cells, the Notch1DE can be cleaved by -secretase and active Notch1 NICD is released to nucleus. The kit also contains a CSL (CBF1/RBP-J) luciferase reporter vector, which is a Notch pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimerized CSL responsive element upstream of a minimal promoter. The CSL (CBF1/RBP-J) reporter is premixed with constitutively expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency._x000D_The kit also includes a non-inducible firefly luciferase vector premixed with constitutivelyexpressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway specific effects and background luciferase activity.

Notch Reporter Assay Kit (cAMP/PKA Pathway)
GWB-PS79B7 500reactions Ask for price

Notch Signaling Pathway Notch1/CSL Reporter - HEK293 Cell Line
60652 2 vials
EUR 2175
Description: The Notch CSL Reporter - HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) alone with expression construct for Notch1 E (NOTCH1 that has a deletion of the entire extracellular domain) stably integrated into HEK293 cells. Inside the cells, the Notch1 E can be cleaved by γ-secretase. The active Notch1 NICD is released to nucleus and induces the constitutive expression of luciferase reporter. The cell line is validated for the inhibition of the expression of luciferase reporter using a known inhibitor of the Notch signaling pathway.

Notch Signaling Pathway Notch1/CSL Report Cell Line-HEK293
ABC-RC123D 1 vial Ask for price
Description: The Notch CSL Reporter andndash; HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) alone with expression construct for Notch1 E (NOTCH1 that has a deletion of the entire extracellular domain) stably integrated into HEK293 cells. Inside the cells, the Notch1 E can be cleaved by andgamma;-secretase. The active Notch1 NICD is released to nucleus and induces the constitutive expression of luciferase reporter. The cell line is validated for the inhibition of the expression of luciferase reporter using a known inhibitor of the Notch signaling pathway.

Human Notch Signaling Pathway Notch1/CSL Reporter Cell Line-HEK293
ABC-RC0116 1 vial Ask for price
Description: Human Notch Signaling Pathway Notch1/CSL Reporter Cell Line is derived from HEK293. Application: • Monitor Notch signaling pathway activity.• Screen for activators or inhibitors of the Notch signaling pathway.

Transfection Collection™ : Notch1/CSL Transient Pack (Notch Signaling Pathway)
79285 500 rxns.
EUR 715
Description: The Notch1/CSL Transient Packis designed to provide the tools necessary for transiently transfecting and monitoring the activity of the Notch signaling pathway in HEK293 cultured cells. The kit contains transfection-ready vectors containing firefly luciferase as a Notch pathway-responsive reporter and constitutively expressing Renilla luciferase as a transfection control. It also includes the Dual Luciferase detection reagents to detect both luciferase activities and specialized medium for growing and assaying HEK293 cells._x000D_The key to the Notch1/CSL Transient Pack is the expression vector for NOTCH1 that has a deletion of the entire extracellular domain (Notch1DE). Inside the cells, the NOTCH1 DE can be cleaved by γ-secretase and active NOTCH1 NICD is released into the nucleus. The kit also contains CSL (CBF1/RBP-Jk) luciferase reporter vector, which is a Notch pathway-responsive reporter. This reporter contains the firefly luciferase gene under the control of multimerized CSL responsive elements upstream of a minimal promoter. The CSL (CBF1/RBP-Jk) reporter is premixed with constitutively expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency._x000D_The pack also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway specific effects and background luciferase activity._x000D_Additionally, the pack includes cell culture medium (BPS Medium 1) that has been optimized for use with HEK293 cells*. BPS Medium 1 includes MEM medium, 10% fetal bovine serum, 1% non-essential amino acids, sodium pyruvate, and 1% Pen/Strep. Finally, the pack provides the Dual Luciferase (Firefly-Renilla) Assay System. These luciferase reagents provide highly sensitive, stable detection of firefly luciferase activity and Renilla luciferase activity. The dual luciferase reagents can be used directly in cells in growth medium, and can be detected with any luminometer; automated injectors are not required. _x000D_*Note: the kit may be used with other cell lines than HEK293, but an alternate cell culture medium may be required for optimal cell growth,

GWB-PS79B7-500T - Notch Reporter Assay Kit (cAMP/PKA Pathway)
GWB-PS79B7-500T 10ug
EUR 623.05

GWB-PS79B7-500RXN - Notch Reporter Assay Kit (cAMP/PKA Pathway)
GWB-PS79B7-500RXN 500
EUR 849

Notch1 NICD Pathway Reporter Kit (Mouse)
79504 500 rxns.
EUR 590
Description: Notch Pathway Reporter kit is designed for monitoring the activity of the Notch signaling pathway in cultured cells. The kit contains a transfection-ready expression vector for Mouse NOTCH1 that has a deletion of the entire extracellular domain and transmembrane region (NOTCH1 NICD). Inside the cells, the NOTCH1 NICD is constitutively localized into the nucleus without needing to be cleaved by γ-secretase. The kit also contains CSL (CBF1/RBP-Jκ) luciferase reporter vector, which is a Notch pathway-responsive reporter. This reporter contains the firefly luciferase gene under the control of multimerized CSL responsive elements upstream of a minimal promoter. The CSL (CBF1/RBP-Jκ) reporter is premixed with constitutively expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency._x000D_The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway specific effects and background luciferase activity._x000D_This kit contains the expression vector for Mouse Notch1 NICD, which does not require γ-secretase processing to become active. We also offer the Mouse Notch1DE expression vector (BPS Bioscience #60509), as well as a Human Notch1DE expression vector (BPS Bioscience #79503), which are dependent on γ-secretase activity to become active.

IDO Pathway inhibitor
2746-250 each
EUR 392.4

IDO Pathway inhibitor
2746-50 each
EUR 144

Akt Pathway Sampler Kit
E051001 5x50ug
EUR 475
Description: Available in various conjugation types.

Akt Pathway Sampler Kit
MBS8505956-5x005mg 5x0.05mg
EUR 575

Wnt pathway activator 1
MBS133516-INQUIRE INQUIRE Ask for price

Wnt pathway inhibitor 3
HY-153750 10 mg
EUR 54.11
Description: Wnt pathway inhibitor 3 is a potent wnt inhibitor with an IC50 value of 45 nM. Wnt pathway inhibitor 3 shows antiproliferative activity[1].

Wnt pathway inhibitor 4
HY-153753 10 mg
EUR 54.11
Description: Wnt pathway inhibitor 4 (compound 16D) is an anticancer agent that has anti-proliferative activity[1].

Wnt pathway activator 2
HY-136073 10 mg
EUR 919.93
Description: Wnt pathway activator 2 is a potent Wnt activator extracted from patent WO2012024404A1, compound 2, has an EC50s of 13 nM[1].

MAPK Pathway Sampler Kit
E051017 5x50ug
EUR 475
Description: Available in various conjugation types.

NFκB Pathway Sampler Kit
E051021 5x50ug
EUR 475
Description: Available in various conjugation types.

Wnt pathway activator 1
MBS5755712-10mg 10mg
EUR 210

Wnt pathway activator 1
MBS5755712-25mg 25mg
EUR 305

Wnt pathway activator 1
MBS5755712-2mg 2mg
EUR 155

Wnt pathway activator 1
MBS5755712-50mg 50mg
EUR 435

Wnt pathway activator 1
MBS5755712-5mg 5mg
EUR 180

Wnt pathway activator 2
MBS5767862-5mg 5mg
EUR 915

Wnt pathway activator 2
MBS5767862-5x5mg 5x5mg
EUR 3970

MAPK Pathway Sampler Kit
MBS8504436-5x005mg 5x0.05mg
EUR 575

Wnt pathway activator 1
T17256-10mg 10mg Ask for price
Description: Wnt pathway activator 1

Wnt pathway activator 1
T17256-1g 1g Ask for price
Description: Wnt pathway activator 1

Wnt pathway activator 1
T17256-1mg 1mg Ask for price
Description: Wnt pathway activator 1

Wnt pathway activator 1
T17256-50mg 50mg Ask for price
Description: Wnt pathway activator 1

Wnt pathway activator 1
T17256-5mg 5mg Ask for price
Description: Wnt pathway activator 1

Wnt pathway activator 2
T13345-10mg 10mg Ask for price
Description: Wnt pathway activator 2

Wnt pathway activator 2
T13345-1g 1g Ask for price
Description: Wnt pathway activator 2

Wnt pathway activator 2
T13345-1mg 1mg Ask for price
Description: Wnt pathway activator 2

Wnt pathway activator 2
T13345-50mg 50mg Ask for price
Description: Wnt pathway activator 2

Wnt pathway activator 2
T13345-5mg 5mg Ask for price
Description: Wnt pathway activator 2

Integrin Pathway Sampler Kit
E051025 5x50ug
EUR 475
Description: Available in various conjugation types.

Integrin Pathway Sampler Kit
MBS8503104-5x005mg 5x0.05mg
EUR 575

NFkappaB Pathway Sampler Kit
MBS8503740-5x005mg 5x0.05mg
EUR 575

Hh Signaling Pathway Antagonist
1659-1 each
EUR 216

Tissue factor pathway inhibitor
AP79938 1mg
EUR 2640

Tissue factor pathway inhibitor
AP88123 1mg
EUR 2640

Tissue factor pathway inhibitor
AP89055 1mg
EUR 2640

AP1 Reporter Kit (JNK Pathway)
60612 500 rxns.
EUR 565
Description: The AP1 Reporter Kit is designed for monitoring the activity of the JNK signaling pathway and the transcriptional activity of AP1 in cultured cells. The kit contains a transfection-ready AP1 luciferase reporter vector. This reporter contains the firefly luciferase gene under the control of multimerized AP1 responsive elements located upstream of a minimal promoter. The AP1 reporter is premixed with a constitutively-expressing Renilla (sea pansy) luciferase vector that serves as an internal control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains the firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical for determining pathway-specific effects and the background luciferase activity.

AP1 Reporter Kit (JNK Pathway)
GWB-PSB7DB 500reactions Ask for price

JAK/STAT Pathway Sampler Kit
E051015 5x50ug
EUR 475
Description: Available in various conjugation types.

JAK/STAT Pathway Sampler Kit
MBS8503095-5x005mg 5x0.05mg
EUR 575

Human Calcium Regulation Pathway
HCAR-I 1 set
EUR 657.6

β -Catenin Pathway Sampler Kit
E051023 5x50ug
EUR 475
Description: Available in various conjugation types.

Phospho-AKT Pathway Sampler Kit
E051002 5x50ug
EUR 700
Description: Available in various conjugation types.

Phospho-PLC Pathway Sampler Kit
E051020 5x50ug
EUR 700
Description: Available in various conjugation types.

Phospho-AKT Pathway Sampler Kit
MBS8500044-5x005mg 5x0.05mg
EUR 800

Phospho-PLC Pathway Sampler Kit
MBS8500057-5x005mg 5x0.05mg
EUR 800

MTOR Pathway Antibody Sampler Kit
HAK21036 1 Kit Ask for price

Tissue factor pathway inhibitor 2
AP79755 1mg
EUR 2640

Tissue factor pathway inhibitor 2
AP88049 1mg
EUR 2640

Tissue factor pathway inhibitor 2
AP88141 1mg
EUR 2640

Phospho-MAPK Pathway Sampler Kit
E051018 5x50ug
EUR 700
Description: Available in various conjugation types.

Phospho-NFκB Pathway Sampler Kit
E051022 5x50ug
EUR 700
Description: Available in various conjugation types.

Phospho-MAPK Pathway Sampler Kit
MBS8501740-5x005mg 5x0.05mg
EUR 800

beta-Catenin Pathway Sampler Kit
MBS8503912-5x005mg 5x0.05mg
EUR 575

TOR Signaling Pathway Detection Set
MBS154734-1Set 1Set
EUR 1115

TOR Signaling Pathway Detection Set
MBS154734-5x1Set 5x1Set
EUR 5140

TOR Signaling Pathway Detection Set
PSI-1805 1 Set
EUR 1287.6
Description: The mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle progression through its ability to integrate signals from nutrient levels and growth factors. TOR regulation is accomplished through a network of various activators and repressors. It is phosphorylated by Akt, whose activity is indirectly inhibited by the lipid phosphatase PTEN. TOR is normally associated with the regulatory proteins RAPTOR, a scaffold protein whose binding by TOR substrates is necessary for effective TOR-catalyzed phosphorylation, and GΒL, which stimulates TOR’s kinase activity towards downstream proteins. It is further regulated by the proteins Rheb, TSC1 and TSC2, which act to modulate TOR activity. The downstream targets of TOR are thought to be the ribosomal protein S6 kinases and the eukaryotic initiation factor 4E binding proteins (4EBPs) whose activation leads to increased protein translation and cell growth.;;For images please see PDF data sheet

Human Cancer Pathway Primer Library
HCAN-I 1 set
EUR 657.6

Tissue Factor Pathway Inhibitor TFPI
MBS606041-01mg 0.1mg
EUR 835

Tissue Factor Pathway Inhibitor TFPI
MBS606041-5x01mg 5x0.1mg
EUR 3610

Tissue Factor Pathway Inhibitor (TFPI)
MBS6508350-01mg 0.1mg
EUR 860

Tissue Factor Pathway Inhibitor (TFPI)
MBS6508350-5x01mg 5x0.1mg
EUR 3725

Human Hippo Signaling Primer Pathway
HHPO-I 1 set
EUR 657.6

FOXO Reporter Kit (PI3K/AKT Pathway)
60643 500 rxns.
EUR 565
Description: The FOXO Reporter kit is designed to monitor activity of the PI3K/AKT signaling pathway and the transcriptional activity of FOXO proteins in cultured cells. The kit contains the transfection-ready FOXO3 expression vector and the FOXO luciferase reporter vector, which is a PI3K/Akt pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimers of the FOXO responsive element located upstream of a minimal promoter. The FOXO reporter is premixed with a constitutively-expressing Renilla (sea pansy) luciferase vector, which serves as an internal control for the transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as negative control. The non-inducible luciferase vector also contains the firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical to determining pathway-specific effects and background luciferase activity.

Phospho-Integrin Pathway Sampler Kit
E051026 5x50ug
EUR 700
Description: Available in various conjugation types.

Phospho-Integrin Pathway Sampler Kit
MBS8505471-5x005mg 5x0.05mg
EUR 800

Phospho-NFkappaB Pathway Sampler Kit
MBS8505981-5x005mg 5x0.05mg
EUR 800

PDK1/Akt/Flt dual pathway inhibitor
HY-129426 Get quote Ask for price
Description: PDK1/Akt/Flt dual pathway inhibitor is one of a component of KP372-1 (HY-15673 ), and inhibits PDK1/Akt/Flt dual pathway[1].

JAK pathway ISRE reporter cell line
GWB-PSC83D 1.5x10(6)cells Ask for price

NF-κB Pathway Antibody MiniAb Set
S0M1004 1 Kit Ask for price

Tissue Factor Pathway Inhibitor Antibody
GWB-626C0B 0.1 mg Ask for price

Myc Reporter Kit (Myc Signaling Pathway)
60519 500 rxns.
EUR 625
Description: The Myc Pathway Reporter kit is designed for monitoring the activity of the Myc signaling pathway in cultured cells. The kit contains a transfection-ready expression vector for c- Myc and Myc luciferase reporter vector. Inside the cells, c-Myc will bind to Max, translocate to the nucleus, and induce expression of the Myc luciferase reporter vector. This reporter contains the firefly luciferase gene under the control of multimerized Myc responsive elements located upstream of a minimal promoter. The Myc reporter is premixed with constitutively-expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency._x000D_The kit also includes a non-inducible firefly luciferase vector premixed with constitutivelyexpressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway-specific effects and background luciferase activity.

Phospho-JAK/STAT Pathway Sampler Kit
E051016 5x50ug
EUR 700
Description: Available in various conjugation types.

Phospho-JAK/STAT Pathway Sampler Kit
MBS8503469-5x005mg 5x0.05mg
EUR 800

Tissue Factor Pathway Inhibitor 2 (TFPI2)
MBS6508351-01mg 0.1mg
EUR 845

Tissue Factor Pathway Inhibitor 2 (TFPI2)
MBS6508351-5x01mg 5x0.1mg
EUR 3660

Tissue Factor Pathway Inhibitor 2 (TFPI2)
MBS6508352-01mg 0.1mg
EUR 875

Tissue Factor Pathway Inhibitor 2 (TFPI2)
MBS6508352-5x01mg 5x0.1mg
EUR 3785

TGF-beta Fibrosis Pathway Antibody Kit
HAK21004 1 Kit Ask for price

ARE Reporter Kit (Nrf2 Antioxidant Pathway )
60514 500 rxns.
EUR 650
Description: The ARE Reporter kit is designed for monitoring the activity of the Nrf2 antioxidant pathway in cultured cells. The kit contains a transfection-ready ARE luciferase reporter vector, which is an Nrf2 pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimerized ARE responsive elements located upstream of a minimal promoter. The ARE reporter is premixed with a constitutively expressing Renilla (sea pansy) luciferase vector that serves as an internal control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively expressing Renilla luciferase vector as negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, without any additional response elements. This negative control is critical to determining pathway-specific effects and background luciferase activity.

Phospho-β-Catenin Pathway Sampler Kit
E051024 5x50ug
EUR 700
Description: Available in various conjugation types.

STAT3 Reporter Kit (STAT3 Signaling Pathway)
79730 500 rxns.
EUR 640
Description: The STAT3 Reporter kit is designed for monitoring the activity of the STAT3 signaling pathway in cultured cells. The kit contains transfection-ready STAT3 luciferase reporter vector. This reporter contains a firefly luciferase gene under the control of STAT3-responsive element located upstream of a minimal promoter. The STAT3 reporter is premixed with constitutively expressing Renilla luciferase vector, which serves as an internal control for transfection efficiency._x000D_
The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains the firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical to determining pathway-specific effects and background luciferase activity.

Human Tissue factor pathway inhibitor (TFPI)
1-CSB-EP023437HU
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  • 10ug
  • 50ug
  • 100ug
  • 200ug
  • 500ug
  • 1MG
Description: Recombinant Human Tissue factor pathway inhibitor(TFPI),partial expressed in E.coli

G-protein pathway suppressor 2 Antibody
20-abx137433
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  • 5 ug
  • 20 ug
  • 100 ug

Tissue Factor Pathway Inhibitor 2 Protein
abx263563-10mg 10 mg
EUR 1600

Tissue Factor Pathway Inhibitor 2 Protein
20-abx263563
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  • 1 µg
  • 5 ug
  • 50 ug

Tissue Factor Pathway Inhibitor 2 Protein
abx263563-1mg 1 mg
EUR 225

Tissue Factor Pathway Inhibitor 2 Protein
abx263563-5mg 5 mg
EUR 325