Category: Cell-free culture conditioned medium elicits pancreatic β cell lineage-specific epigenetic reprogramming in mice.

Bovine serum albumin/chitosan-nanoparticle bio-complex; spectroscopic study and in vivo toxicological - Hypersensitivity evaluation

Bovine serum albumin/chitosan-nanoparticle bio-complex; spectroscopic study and in vivo toxicological – Hypersensitivity evaluation

This study, investigates the interplay of bovine serum albumin (BSA) with synthesized chitosan nanoparticles (CSNPs) utilizing regular-state fluorescence and UV-vis absorbance spectroscopy in addition to picosecond time-resolved fluorescence approach. The fluorescence quenching mechanism of BSA by CSNPs signifies the presence of each static and dynamic mechanism. The loading effectivity of BSA-CSNPs exhibited a lower by…

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Improvement in serum amylase and glucose levels in diabetic rats on oral administration of bisdemethoxycurcumin from Curcuma longa and limonoids from Azadirachta indica

Improvement in serum amylase and glucose levels in diabetic rats on oral administration of bisdemethoxycurcumin from Curcuma longa and limonoids from Azadirachta indica

Curcuma longa and Azadirachta indica are historically used in Indian delicacies and Ayurvedic drugs as nutraceuticals towards diabetes. The crude C. longa isopropanol extract, bisdemethoxycurcumin (BDMC), the purified bioactive part from C. longa, and limonoids azadiradione, gedunin from A. indica, are in a position to inhibit in vitro the antidiabetic goal human pancreatic α-amylase independently.…

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Cell-free culture conditioned medium elicits pancreatic β cell lineage-specific epigenetic reprogramming in mice.

Cell-free culture conditioned medium elicits pancreatic β cell lineage-specific epigenetic reprogramming in mice.

There are a number of obstacles to beat previous to reaching mobile reprogramming of pancreatic β cells in vitro and in vivo. The current research demonstrated that the switch of epigenetic phenotypes was achieved in the cell-free conditioned medium (CM) of pancreatic insulinoma MIN6 cell cultures. The comparability of a subpopulation of MIN6, m14 and…

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